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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1982-10-21
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pubmed:abstractText |
Four iodine-125 labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogues of the previously reported selenium-75 labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after intravenous injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 approximately 18 h), which is desirable for brain imaging. In contrast, the benzylamine is rapidly cleared from brain tissue (t1/2 approximately 15 min).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
870-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7108905-Amines,
pubmed-meshheading:7108905-Animals,
pubmed-meshheading:7108905-Benzylamines,
pubmed-meshheading:7108905-Chemical Phenomena,
pubmed-meshheading:7108905-Chemistry,
pubmed-meshheading:7108905-Iodine Radioisotopes,
pubmed-meshheading:7108905-Isotope Labeling,
pubmed-meshheading:7108905-Male,
pubmed-meshheading:7108905-Rats,
pubmed-meshheading:7108905-Rats, Inbred Strains,
pubmed-meshheading:7108905-Time Factors,
pubmed-meshheading:7108905-Tissue Distribution,
pubmed-meshheading:7108905-Xylenes
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pubmed:year |
1982
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pubmed:articleTitle |
Synthesis and tissue distribution study of iodine-labeled benzyl- and xylylamines.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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