Linked Life Data

7105549

Source:http://linkedlifedata.com/resource/pubmed/id/7105549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
168
pubmed:dateCreated
1982-10-12
pubmed:abstractText
The roles of matrix antigens, link proteins (LP) and proteoglycan monomer (PG) were investigated with regard to the late rejection of joint allografts. Antisera to these antigens were produced in the rabbit. With the use of immunofluorescent techniques, these antigens can be detected in host synovium as early as six weeks after transplantation. At about 12 weeks, antibody reaction against LP and PG was detected in the recipient synovium and circulation. After transplantation there is apparently a slow release of antigen from the cartilage matrix that is concentrated within the synoviun. An immune response occurs in the tissue which subsequently becomes transformed into a pannus and ultimately destroys the allograft. Whether the humoral response observed is primarily responsible for allograft rejection has not been determined. LP and PG could evoke a cytotoxic response that is more significant. Histocompatibility antigens could be primarily responsible for allograft rejection and the humoral response to LP and PG may be a secondary phenomenon.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Matrix antigens in allografts. The humoral response.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.