Linked Life Data

7104752

Source:http://linkedlifedata.com/resource/pubmed/id/7104752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-10-21
pubmed:abstractText
Pieces of cerebellar primordia were dissected from the developing fetus at day 18 of gestation in Sprague-Dawley rats and transplanted to the neocortex of a 10- to 12-day-old rat. The histological development of 53 such transplants was analyzed at a series of survival times ranging from 5 min to 426 days. The cerebellar cortex developed much as it does in situ. However, only migratory sequences were strictly followed, while Purkinje cell differentiation and folia formation were initially retarded. In deep parts of the transplant, and throughout transplants confined to deep layers of the neocortex, the external granule layer was associated with penetrating blood vessels. An inverted cytoarchitectural pattern developed as concentric cylindrical layers around these vessels. In contrast, normal lamination and foliation were found only in transplants growing on the neocortical surface. Axons coursing between host and transplant were seen frequently and were especially pronounced at those sites beneath the internal granule layer which appeared to contain deep cerebellar nuclei. At the longest survival time there was preliminary evidence that suggested morphological deterioration of the transplant. Surface transplants, in addition to developing a normal orientation of cells and layers, have the added benefit of being accessible for further experimental manipulations after the transplant has become established.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-79
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The development of cerebellar primordia transplanted to the neocortex of the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't