Linked Life Data

7104332

Source:http://linkedlifedata.com/resource/pubmed/id/7104332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-10-21
pubmed:abstractText
We have used Raman spectroscopy to investigate the effects of the general anaesthetics halothane and chloroform on lipid bilayer order. Clinical concentrations of these anaesthetics had no significant effect on the hydrocarbon chain conformation in multilamellar vesicles of dimyristoylphosphatidylcholine/cholesterol. This result was obtained with a technique sufficiently precise to monitor changes in the acyl chain trans-gauche population ratio associated with a 1-2 K alteration in temperature. Very high levels of anaesthetics caused a marked disordering of the hydrocarbon chains. The danger of inferring an effect at clinical concentrations from data obtained at much higher levels is illustrated by a statistical analysis of our dose-response curves.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
688
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
388-98
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Do clinical levels of general anaesthetics affect lipid bilayers? Evidence from Raman scattering.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't