Linked Life Data

7104205

Source:http://linkedlifedata.com/resource/pubmed/id/7104205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-10-12
pubmed:abstractText
Histamine is liberated in the inflammatory reaction and has been reported to inhibit epidermal cell division in vitro. This study has investigated the effects of histamine and HI and H2 antagonists on epidermopoiesis in vivo in man. No direct stimulatory effect of histamine was detected for normal epidermis. A combination of HI antagonist (chlorpheniramine) and H2 antagonist (cimetidine) led to further increases in epidermal labelling indices in mitotically stimulated epidermis. The administration of HI antagonist alone led to a decrease in mean epidermal thickness. These data suggest that histamine release is unlikely to play a major role in the hyperplasia of inflammatory dermatoses, but that it may be possible to influence epidermal reactions via the HI and H2 receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0007-0963
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Histamine and epidermal proliferation.
pubmed:publicationType
Journal Article, Comparative Study