Linked Life Data

7098149

Source:http://linkedlifedata.com/resource/pubmed/id/7098149

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-9-24
pubmed:abstractText
The effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on the protein synthesis in rat liver was studied in vivo and in vitro. Oral administration of malotilate to rats caused an increase in the protein and RNA contents of the liver and lef to an acceleration of 14C-leucine incorporation into microsomal and cytosol proteins. In a cell-free system, the protein synthesis was enhanced by treatment with malotilate, and an unknown factor(s) which participates in the protein synthesis was found in the cytosol fraction prepared from malotilate treated livers. These results suggest that malotilate is a new type of inducer for protein synthesis. On the basis of the observations obtained in the present study, a hypothesis can be formulated that malotilate enhances liver protein synthesis by accelerating RNA synthesis and/or increasing the transport of RNA from nuclei to cytosol in rat liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-5198
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-75
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on the protein synthesis in rat liver.
pubmed:publicationType
Journal Article