Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1982-9-24
|
pubmed:abstractText |
A series of 33 1H-benz[de]isoquinolinecarboximidamides has been prepared and tested in the rat after intraperitoneal (ip) and/or oral (po) administration for their ability to inhibit the in vivo blood platelet aggregation induced by collagen. In this aggregation test, a considerable number of active compounds were found. Fourteen compounds were active when administered in [0.2 (mmol/kg)/day], five of which also exhibited significant po activity. One compound was toxic after ip administration but was found to be active after po administration without apparent toxicity. It is thought that the solubility of the drug in water is an important factor for the resorption after oral administration and, hence, for its oral activity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
714-9
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:7097724-Animals,
pubmed-meshheading:7097724-Chemical Phenomena,
pubmed-meshheading:7097724-Chemistry,
pubmed-meshheading:7097724-Collagen,
pubmed-meshheading:7097724-Isoquinolines,
pubmed-meshheading:7097724-Male,
pubmed-meshheading:7097724-Platelet Aggregation,
pubmed-meshheading:7097724-Rats,
pubmed-meshheading:7097724-Rats, Inbred Strains,
pubmed-meshheading:7097724-Solubility
|
pubmed:year |
1982
|
pubmed:articleTitle |
Inhibitors of blood platelet aggregation. Activity of some 1H-benz[de]isoquinolinecarboximidamides on the in vivo blood platelet aggregation induced by collagen.
|
pubmed:publicationType |
Journal Article
|