Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1982-9-24
|
| pubmed:abstractText |
A method is described to measure the in vitro metabolism of theophylline by liver microsomes. The formation of 1-methyluric acid and 1,3-dimethyluric acid in incubation mixtures was determined by high-performance liquid chromatography. The formation of both metabolites was linear with time and the formation of 1-methyluric acid was blocked by allopurinol. This method will be useful in assessing potential drug interactions involving theophylline.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-3549
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
712-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1982
|
| pubmed:articleTitle |
The measurement of theophylline metabolism in hepatic microsomes using high-performance liquid chromatography.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|