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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0030705,
umls-concept:C0036525,
umls-concept:C0076533,
umls-concept:C0175630,
umls-concept:C0205216,
umls-concept:C0229671,
umls-concept:C0439680,
umls-concept:C0441889,
umls-concept:C0685938,
umls-concept:C1522484,
umls-concept:C1707520,
umls-concept:C2828008
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pubmed:issue |
1
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pubmed:dateCreated |
1982-9-10
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pubmed:abstractText |
Using a cytotoxicity assay, we have shown that all of 40 normal human sera tested contained antibodies cytotoxic for neuraminidase-treated red blood cells in the presence of complement. The antibodies were shown to be specific for the T disaccharide by studies using a synthetic T antigen (formula: see text). Certain patients with metastatic gastrointestinal cancer were found to have depressed serum levels of anti-T when compared to normal controls. There was a correlation between depression of circulating anti-T and disease burden in that 83% of patients with extensive disease had lower than normal levels of cytotoxic anti-T as compared to 45% of patients with moderate disease and none with minimal disease. There was no correlation between the concentration of cytotoxic anti-T and the age of the patients, time since surgery or the type of therapy the patient was receiving. Patients with low levels of cytotoxic anti-T had normal levels of cytotoxic anti-sheep red blood cell antibody. Measurement of circulating anti-T in the serum of certain cancer patients may prove valuable in the monitoring of disease progression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-1133848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-13272119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-163330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-220469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-372653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-374421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-386359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-489058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-4979781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-51034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-5487543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-593323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-6168373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-68564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-6971015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-7010609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-7217675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-7417937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-7417939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7094422-74917
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1982
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pubmed:articleTitle |
Decreased levels of circulating lytic anti-T in the serum of patients with metastatic gastrointestinal cancer: a correlation with disease burden.
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pubmed:publicationType |
Journal Article
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