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pubmed-article:7093904pubmed:abstractTextFourteen previously untreated patients with metastatic nonseminomatous germ-cell cancer of the testis (NSGC) were treated with a modified VAB-4 regimens that was designed to reduce treatment-related morbidity. Nine of ten patients with minimal disease and the only patient with advanced pulmonary disease achieved a complete response (CR) with chemotherapy alone. Two of three partial responders with advanced abdominal disease were converted to CR status with radiotherapy and/or surgery. None of the 12 CRs has had a relapse (median duration of follow-up, 28+ months). We observed no granulocytopenic fever or permanent renal insufficiency. These results indicate that NSGC patients with a low tumor burden can be spared substantial toxicity without the complete response rates being adversely affected.lld:pubmed
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pubmed-article:7093904pubmed:articleTitleNonseminomatous germ-cell cancer of the testis.lld:pubmed
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pubmed-article:7093904pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed