Linked Life Data

7091733

Source:http://linkedlifedata.com/resource/pubmed/id/7091733

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-8-26
pubmed:abstractText
The effect of low potassium diets with and without deoxycorticosterone (DOCA), furosemide, chlorothiazide, or ethacrynic acid on sensitivity of isolated guinea pig lumbrical nerve-muscle preparations to d-tubocurarine was examined. The ED50 of d-tubocurarine was found to fall as the potassium level was lowered by dietary restriction. Addition of DOCA or furosemide was without effect while chlorothiazide reduced and ethacrynic acid enhanced the effect of diet alone. Acute restoration of potassium levels of 5.9 mM reversed considerably, but not completely, the effect of chronic depletion. Thus, a patient suffering from chronic potassium depletion would be expected to require a decreased dose of d-tubocurarine, and although acute replacement of potassium preoperatively would tend to return the dose requirement toward normal, such reversal might not be complete.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Chronic potassium depletion and sensitivity to tubocurarine.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.