Linked Life Data

7091364

Source:http://linkedlifedata.com/resource/pubmed/id/7091364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Cardiac uptake and secretion of epinephrine (Epi) and norepinephrine (NE) were studied at rest and during the response to systemic vasodilation with dipyridamole in conscious dogs. Chronically implanted catheters in the left atrium and anterior great coronary vein allowed simultaneous measurement of arterial and venous levels of NE and Epi across the segment of myocardium perfused by the left anterior descending coronary artery. Arterial Epi was greater than coronary venous Epi both at rest and during vasodilation. Arterial and venous NE levels were similar at rest. However, arterial NE rose more than venous NE during dipyridamole. Thus, there was net cardiac uptake of NE as well as Epi when systemic plasma catecholamine levels increased in response to vasodilation. Fractional extraction [(A-V)/A X 100)] of Epi by the heart was 50% and was not affected over a sevenfold range of coronary artery flow. Fractional extraction of NE (5-15%) was significantly lower than that of Epi, most likely due to cardiac secretion of NE. Cardiac NE secretion was estimated to increase fourfold during dipyridamole. Thus, cardiac tissue of trained dogs avidly takes up circulating catecholamines. Despite an apparent increase of NE secretion by the heart during the systemic adrenergic response to dipyridamole, the heart remained an organ of net NE uptake and therefore did not contribute to the observed increase of systemic NE levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
243
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E52-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Cardiac uptake and secretion of catecholamines during adrenergic stimulation in vivo.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.