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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1982-8-7
|
| pubmed:abstractText |
Because of divergent conclusions in the literature regarding the effects of temperature on end-diastolic compliance in the canine left ventricle (LV), pressure-volume relationships at normothermia and hypothermia (28 degrees C) were studied with two-dimensional ultrasound in nine dogs on cardiopulmonary bypass (open pericardium) over a range of left ventricular end-diastolic pressure (LVEDP) from 0 to 22 mm Hg. Three perpendicular echocardiographic sections were used with Simpson's rule to measure LV volume and mass at end-diastole for each level of LVEDP. Temperature was varied between 37 degrees and 28 degrees C by systemic cooling, and heart rate was allowed to slow spontaneously with temperature reduction. There was no change in left ventricular end-diastole pressure-volume (LVEDP-LVEDV) relationships at lower temperature provided that ventricular relaxation was complete at end-diastole. In addition, serial postmortem pressure-volume curves carried out by direct saline infusion into sealed ventricles at 38 degrees and 28 degrees C in three additional dogs demonstrated no temperature effects on postmortem LV compliance. Postmortem mass correlated well with echocardiographically determined LV mass, which showed a significant increase during the period of cardiopulmonary bypass, correlating with the development of myocardial edema. In summary, there appears to be no effect of moderate hypothermia on LVEDP-LVEDV relationships, provided the heart is in true diastasis at end-diastole. In addition, echocardiographic techniques can be used to study LV mass change on cardiopulmonary bypass.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-5223
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
878-90
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7087515-Animals,
pubmed-meshheading:7087515-Cardiac Volume,
pubmed-meshheading:7087515-Cardiopulmonary Bypass,
pubmed-meshheading:7087515-Diastole,
pubmed-meshheading:7087515-Dogs,
pubmed-meshheading:7087515-Echocardiography,
pubmed-meshheading:7087515-Heart Rate,
pubmed-meshheading:7087515-Hypothermia, Induced,
pubmed-meshheading:7087515-Pressure,
pubmed-meshheading:7087515-Statistics as Topic,
pubmed-meshheading:7087515-Ventricular Function
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
The absence of temperature effects on end-diastolic pressure-volume relations in the canine left ventricle determined by two-dimensional echocardiography.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|