Linked Life Data

7086837

Source:http://linkedlifedata.com/resource/pubmed/id/7086837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-8-14
pubmed:abstractText
Nine pyrimidine nucleoside analogues, in which the group attached at N-1 is a six-membered ring containing two heteroatoms, have been synthesized using the Vorbrüggen and Bennua (Vorbrüggen, H.; Bennua, B. Tetrahedron Lett. 1978, 1339) coupling procedure. These are 1-(1,4-oxathian-3-yl)-5-fluorouracil (8), 1-(4-oxo-1,4-oxathian-3-yl)-5-fluorouracil (two stereoisomers 9 and 10, resolved by silica gel column chromatography, 1-(1,4-oxathian-3-yl)-5-fluorouracil (11), 1-(1,4-oxathian-2-yl)-5-fluorouracil (12), 1-(1,4-dithin-2-yl)-5-flourouracil (15), 1-(1,4-dithian-2-yl)uracil (16), 1-(1,4-dithian-2-yl)thymine (17), and 1-(1,4-dioxan-2-yl)-5-fluorouracil (20). All of the analogous were tested for cell-growth inhibition using mouse and human tumor cell lines. The ID50 values of all of the analogues are greater than 10(-4) M, except in the case of 11 using the L1210 cell line. The most active analogues found are compounds 11 and 17, which were found to be 100 and 200 times less active, respectively, than 5-fluorouracil in the human erythroleukemia cell line, K-562.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Synthesis and biological evaluation of novel pyrimidine nucleoside analogues of 1,4-oxathiane, 1,4-dithiane, and 1,4-dioxane.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't