Linked Life Data

7085673

Source:http://linkedlifedata.com/resource/pubmed/id/7085673

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Several insect toxic components were isolated from the venom of the chactoid scorpion, Scorpio maurus palmatus (Scorpionidae), by column chromatography, with the following findings. 1) The toxicity of the crude venom to insects is due to three separate groups of substances, the so-called cytotoxins, phospholipases, and neurotoxins, which play a dominant role. 2) The neurotoxic fraction contains two factors: the fast reversibly paralytic and the slow lethal. 3) The slow lethal factor is composed of two toxins (IT1 and IT2), the purity of which was assessed by column chromatography, disc electrophoresis, isoelectrofocusing, analytical ultracentrifugation, and amino acid analyses. 4) IT1 and IT2 are two polypeptides possessing unique amino acid compositions with molecular weights of 3232 and 3963, pHi 8.8 and 9.2, and supposed to contain two and three disulfide bridges, respectively. 5) A clear cooperative interaction was demonstrated between the fast paralytic and lethal fractions as well as between the two insect toxins, resulting in an evident recovery of the original toxicity to insects of the crude venom. 6) When assayed on an isolated insect axonal preparation under current and voltage clamp conditions, the combination of IT1 and IT2 caused a reversible blockage of both the sodium and potassium currents. This may explain the specific symptomatology and the mechanism of the paralysis induced by these toxins to an insect. The above data were compared with information concerning buthoid scorpion venom insect toxins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8397-404
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Insect toxic component from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae).
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S.