| pubmed-article:7085635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7085635 | lifeskim:mentions | umls-concept:C0039067 | lld:lifeskim |
| pubmed-article:7085635 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:7085635 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:7085635 | lifeskim:mentions | umls-concept:C0178649 | lld:lifeskim |
| pubmed-article:7085635 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:7085635 | pubmed:dateCreated | 1982-8-26 | lld:pubmed |
| pubmed-article:7085635 | pubmed:abstractText | The energetics of active transport of gamma-aminobutyric acid (GABA) by neuronal synapses has been studied using preparations of synaptosomes from rat brain. The maximal (steady state) accumulation of GABA by synaptosomes was measured as a function of the transmembrane potassium concentration gradient (which is equal to the transmembrane electrical potential in this system), the sodium concentration gradient, and the external chloride concentration. The steady state [GABA]i/[GABA]o increased as the second power of [K+]i/[K+]o which indicates that GABA is transported with a net charge of +2. The GABA gradient was dependent on [Na+]o/[Na+]i to a power of between 1.2 and 2.1 but was almost independent of [Cl-]. It is concluded that a neutral GABA molecule is cotransported with 2 Na+ to give a net charge of +2. The coupling of GABA transport to the transmembrane electrical potential and the Na+ concentration gradient is sufficient to provide the energy for the measured GABA concentration gradient in rat brain synaptosomes. | lld:pubmed |
| pubmed-article:7085635 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7085635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7085635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7085635 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7085635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7085635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7085635 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7085635 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7085635 | pubmed:author | pubmed-author:WilsonD FDF | lld:pubmed |
| pubmed-article:7085635 | pubmed:author | pubmed-author:PastuszkoAA | lld:pubmed |
| pubmed-article:7085635 | pubmed:author | pubmed-author:ErecinskaMM | lld:pubmed |
| pubmed-article:7085635 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7085635 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:7085635 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:7085635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7085635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7085635 | pubmed:pagination | 7514-9 | lld:pubmed |
| pubmed-article:7085635 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7085635 | pubmed:meshHeading | pubmed-meshheading:7085635-... | lld:pubmed |
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| pubmed-article:7085635 | pubmed:meshHeading | pubmed-meshheading:7085635-... | lld:pubmed |
| pubmed-article:7085635 | pubmed:meshHeading | pubmed-meshheading:7085635-... | lld:pubmed |
| pubmed-article:7085635 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7085635 | pubmed:articleTitle | Energetics of gamma-aminobutyrate transport in rat brain synaptosomes. | lld:pubmed |
| pubmed-article:7085635 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7085635 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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