Linked Life Data

7085635

Source:http://linkedlifedata.com/resource/pubmed/id/7085635

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1982-8-26
pubmed:abstractText
The energetics of active transport of gamma-aminobutyric acid (GABA) by neuronal synapses has been studied using preparations of synaptosomes from rat brain. The maximal (steady state) accumulation of GABA by synaptosomes was measured as a function of the transmembrane potassium concentration gradient (which is equal to the transmembrane electrical potential in this system), the sodium concentration gradient, and the external chloride concentration. The steady state [GABA]i/[GABA]o increased as the second power of [K+]i/[K+]o which indicates that GABA is transported with a net charge of +2. The GABA gradient was dependent on [Na+]o/[Na+]i to a power of between 1.2 and 2.1 but was almost independent of [Cl-]. It is concluded that a neutral GABA molecule is cotransported with 2 Na+ to give a net charge of +2. The coupling of GABA transport to the transmembrane electrical potential and the Na+ concentration gradient is sufficient to provide the energy for the measured GABA concentration gradient in rat brain synaptosomes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7514-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Energetics of gamma-aminobutyrate transport in rat brain synaptosomes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.