Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1982-8-7
|
pubmed:abstractText |
Twenty-four patients with epidermoid carcinoma of the esophagus have been treated, in a phase II trial, with methyl-GAG using a weekly schedule. Eighteen patients had received prior chemotherapy with cisplatin-containing combinations. Of 23 evaluable patients, four (17%) had partial remissions, each lasting 2 months. All patients had received prior chemotherapy. Toxic effects were manageable and included mild nausea and vomiting, mucositis, and fatigue. Using this schedule, methyl-GAG had modest activity in esophageal cancer, with acceptable toxicity. Its role in combination chemotherapy remains to be defined.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0361-5960
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1427-9
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7083245-Aged,
pubmed-meshheading:7083245-Carcinoma, Squamous Cell,
pubmed-meshheading:7083245-Drug Evaluation,
pubmed-meshheading:7083245-Esophageal Neoplasms,
pubmed-meshheading:7083245-Female,
pubmed-meshheading:7083245-Guanidines,
pubmed-meshheading:7083245-Humans,
pubmed-meshheading:7083245-Male,
pubmed-meshheading:7083245-Middle Aged,
pubmed-meshheading:7083245-Mitoguazone
|
pubmed:year |
1982
|
pubmed:articleTitle |
Phase II study of methyl-GAG in the treatment of esophageal carcinoma.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|