Linked Life Data

7083204

Source:http://linkedlifedata.com/resource/pubmed/id/7083204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8 Suppl
pubmed:dateCreated
1982-8-26
pubmed:abstractText
While the role of estrogens in the maintenance of human breast carcinoma has been firmly established for many years, the sources of this estrogen remain unresolved. Input-output analysis of steroid uptake by breast carcinomas showed no specific uptake of estrogens from blood. Based on the detection of the necessary enzyme systems. Adams and Wong proposed that breast tumors could function as "paraendocrine organs" capable of producing sufficient estradiol (E2) to stimulate their own growth (Adams, J. B., and Wong, M. S. F. Lancet, 2: 1163, 1968). Using the reported values for the concentration of C19 steroid precursors and the rho TTC19-E2 values one can estimate that the contribution of in situ aromatization to the tumor estrogen pool is quite small.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3382s-3386s
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
A reassessment of the role of breast tumor aromatization.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.