| pubmed-article:7080947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C0042960 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C1549078 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C1997894 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:7080947 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7080947 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:7080947 | pubmed:dateCreated | 1982-7-19 | lld:pubmed |
| pubmed-article:7080947 | pubmed:abstractText | Histamine was infused in six normal volunteers at rates of 16, 32, 64 and 96 ng/kg/min increasing at 5-min intervals followed by 128 ng/kg/min for 45 min. Heart rate increased, diastolic blood pressure decreased and skin temperature increased in a dose-dependent fashion. Mean heart rate increased by 15.6 +/- 5.7 beats/min, mean diastolic pressure fell by 8.8 +/- e.2 mmHg and mean skin temperature increased by 1.2 +/- 0.3 degrees C at the highest infusion rate. Mean plasma histamine rose from a basal level of 0.20 +/- 0.03 ng/ml to 1.97 +/- 0.25 ng/ml at the end of the highest infusion rate. The threshold infusion rate for physiological effects was 64-96 ng/kg/min corresponding to 0.77-0.97 ng/ml. Salivary flow was stimulated by 21% after 30 min at the highest dose infusion (P = 0.05). Plasma adrenaline increased 132% but plasma noradrenaline was unchanged. There was a linear decline in heart rate after terminating the histamine infusion with a half time of 82 sec. The half life of infused histamine in the plasma was 102 sec. The clearance of histamine from the plasma was 6.1 %/- 0.2 l/min or 83 ml/kg/min. These concentration effect relationships in normals throw doubt on some of the high endogenous plasma histamine values in the literature. | lld:pubmed |
| pubmed-article:7080947 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7080947 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7080947 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7080947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7080947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7080947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7080947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7080947 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7080947 | pubmed:issn | 0065-4299 | lld:pubmed |
| pubmed-article:7080947 | pubmed:author | pubmed-author:DolleryC TCT | lld:pubmed |
| pubmed-article:7080947 | pubmed:author | pubmed-author:BrownM JMJ | lld:pubmed |
| pubmed-article:7080947 | pubmed:author | pubmed-author:OTAK YKY | lld:pubmed |
| pubmed-article:7080947 | pubmed:author | pubmed-author:MacquinII | lld:pubmed |
| pubmed-article:7080947 | pubmed:author | pubmed-author:LhosteF JFJ | lld:pubmed |
| pubmed-article:7080947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7080947 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:7080947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7080947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7080947 | pubmed:pagination | 12-6 | lld:pubmed |
| pubmed-article:7080947 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7080947 | pubmed:meshHeading | pubmed-meshheading:7080947-... | lld:pubmed |
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| pubmed-article:7080947 | pubmed:meshHeading | pubmed-meshheading:7080947-... | lld:pubmed |
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| pubmed-article:7080947 | pubmed:meshHeading | pubmed-meshheading:7080947-... | lld:pubmed |
| pubmed-article:7080947 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7080947 | pubmed:articleTitle | Concentration effect relationships of infused histamine in normal volunteers. | lld:pubmed |
| pubmed-article:7080947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7080947 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7080947 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7080947 | lld:pubmed |
