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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1982-7-19
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pubmed:abstractText |
Histamine was infused in six normal volunteers at rates of 16, 32, 64 and 96 ng/kg/min increasing at 5-min intervals followed by 128 ng/kg/min for 45 min. Heart rate increased, diastolic blood pressure decreased and skin temperature increased in a dose-dependent fashion. Mean heart rate increased by 15.6 +/- 5.7 beats/min, mean diastolic pressure fell by 8.8 +/- e.2 mmHg and mean skin temperature increased by 1.2 +/- 0.3 degrees C at the highest infusion rate. Mean plasma histamine rose from a basal level of 0.20 +/- 0.03 ng/ml to 1.97 +/- 0.25 ng/ml at the end of the highest infusion rate. The threshold infusion rate for physiological effects was 64-96 ng/kg/min corresponding to 0.77-0.97 ng/ml. Salivary flow was stimulated by 21% after 30 min at the highest dose infusion (P = 0.05). Plasma adrenaline increased 132% but plasma noradrenaline was unchanged. There was a linear decline in heart rate after terminating the histamine infusion with a half time of 82 sec. The half life of infused histamine in the plasma was 102 sec. The clearance of histamine from the plasma was 6.1 %/- 0.2 l/min or 83 ml/kg/min. These concentration effect relationships in normals throw doubt on some of the high endogenous plasma histamine values in the literature.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0065-4299
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7080947-Adult,
pubmed-meshheading:7080947-Blood Pressure,
pubmed-meshheading:7080947-Dose-Response Relationship, Drug,
pubmed-meshheading:7080947-Epinephrine,
pubmed-meshheading:7080947-Heart Rate,
pubmed-meshheading:7080947-Hemodynamics,
pubmed-meshheading:7080947-Histamine,
pubmed-meshheading:7080947-Humans,
pubmed-meshheading:7080947-Infusions, Parenteral,
pubmed-meshheading:7080947-Norepinephrine,
pubmed-meshheading:7080947-Salivation,
pubmed-meshheading:7080947-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Concentration effect relationships of infused histamine in normal volunteers.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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