Linked Life Data

7080839

Source:http://linkedlifedata.com/resource/pubmed/id/7080839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-7-8
pubmed:abstractText
Activation of monocytes with lymphokines from BCG-stimulated lymphocytes increased the capacity to inhibit DNA-synthesis in a tumour cell line (NHIK 3025) at all stages of monocyte maturation in vitro. However, the capacity of monocytes to suppress DNA-synthesis in mixed lymphocyte cultures (MLC) was reduced, indicating a dissociation of the immuno-suppressive and tumour cell cytostatic functions of lymphokine-activated monocytes. Supernatants of lymphokine-activated monocytes inhibited DNA synthesis in the tumour cell line, but not in MLC. Monocytes from donors with a strong tuberculin reaction produced supernatants with a stronger cytostatic activity than monocytes from donors with a weak tuberculin reaction. By in vitro maturation, even the later monocytes acquired ability to produce supernatants that were strongly inhibitory to tumour cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0108-0202
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Dissociation between tumour cell cytostatic and immuno-suppressive capacity of human monocytes activated with lymphokines.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't