Linked Life Data

7080610

Source:http://linkedlifedata.com/resource/pubmed/id/7080610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-7-8
pubmed:abstractText
The stimulation of penetration of Schistosoma mansoni cercariae into agar was studied. This depends exclusively on chemical triggers whose specificity is analyzed in experiments with 230 chemicals. Only aliphatic hydrocarbon chains which have a polar as well as a nonpolar end group are effective. The effectiveness of saturated substances is limited, at pH 7.0, to chain lengths between 10 and 15 carbon atoms. Unsaturated substances are active at longer chain lengths. Their effectiveness is increased by the number of double bonds in the cis position, and these should not be placed too close to the nonpolar end of the chain. As well as double bonds, halogens, hydroxyl groups, and methyl side chains are equally effective. All penetration stimulating substances kill cercariae in free water, and the appropriate chemicals cause this lethality at very low concentrations. It is shown that the host recognition pattern at the stage of penetration is especially adapted to invasion of the human skin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-3255
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-307
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Characterization of chemical stimuli for the penetration of Schistosoma mansoni cercariae. I. Effective substances, host specificity.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't