Linked Life Data

7078003

Source:http://linkedlifedata.com/resource/pubmed/id/7078003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-7-19
pubmed:abstractText
Vasoactive intestinal polypeptide (VIP), in doses of 1, 3, 5, 10 and 30 micrograms dissolved in 10 microliters of physiologic saline, was injected into the anterior chamber of albino rabbit eyes, which had been pretreated with topical 0.5 percent indomethacin. While the blood pressure remained unchanged, the intraocular pressure (IOP) began to rise shortly after injection and reached a maximum in about 20 minutes. An evident dose-response relationship was established between the percentage IOP increase and the dose of VIP. The protein content of the aqueous humor also increased in a dose-dependent manner, and the increases in the IOP and protein content could be significantly correlated. The pupil diameter did not change significantly during the experiments. The sphincter and dilator muscle strips were dissected from the iris of the albino rabbit eye pretreated with 0.5 percent topical indomethacin and incubated in Krebs-Ringer's solution to which VIP was added. A dose-dependent relaxation was induced in the sphincter muscle strip under contraction by 10(-6) M carbachol and also in the dilator muscle under contraction by 3 x 10(-5) M phenylephrine. The ED50 was calculated to be 1.78 x 0.49 x 10(-8) M for the former and 1.91 +/- 0.44 x 10(-9) M (Mean +/- s.e.m.) for the latter muscle strip.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0023-2165
pubmed:author
pubmed:issnType
Print
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-5
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[The effect of vasoactive intestinal polypeptide on the eye (authors transl)].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't