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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1982-7-19
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pubmed:abstractText |
The aim of this study was to determine whether bedtime administration and a low cholesterol diet reduce the minimum effective dose of chenodeoxycholic (chenic) acid, defined as the dose giving a mean cholesterol saturation index of 0.8. Dose response studies were carried out in 10 patients with radiolucent gallstones in a functioning gallbladder during three different treatment regimens. On each regimen, all patients received three different doses of chenodeoxycholic acid in random order for one month each. Bedtime chenic acid plus a low cholesterol diet gave the greatest reduction in saturation index. A significant dose/response relationship was found on each regimen. On the conventional regimen of mealtime chenic acid, the minimum effective dose was 14 mg/kg/day; on bedtime chenic acid it was 12.4 mg/kg/day; and on bedtime chenic acid plus low cholesterol diet it was further reduced to 8.4 mg/kg/day (p less than 0.01). There was a dose-related increase in bowel frequency, which was absent at 10.6 mg/kg/day and below. We conclude that administration of chenic acid at bedtime with a low cholesterol diet enables the minimum effective dose for gallstone dissolution to be approximately halved, thus preventing diarrhoea and reducing the cost of treatment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-1152936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-1178813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-1183049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-13641241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-4117706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-4135688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-435882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-4580472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-4703231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-4746773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-5006919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-5104113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-5645851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-709092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7076005-74722
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
280-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7076005-Adult,
pubmed-meshheading:7076005-Aged,
pubmed-meshheading:7076005-Bile,
pubmed-meshheading:7076005-Chenodeoxycholic Acid,
pubmed-meshheading:7076005-Cholelithiasis,
pubmed-meshheading:7076005-Cholesterol,
pubmed-meshheading:7076005-Cholesterol, Dietary,
pubmed-meshheading:7076005-Dose-Response Relationship, Drug,
pubmed-meshheading:7076005-Drug Administration Schedule,
pubmed-meshheading:7076005-Female,
pubmed-meshheading:7076005-Humans,
pubmed-meshheading:7076005-Male,
pubmed-meshheading:7076005-Middle Aged
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pubmed:year |
1982
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pubmed:articleTitle |
Minimum effective dose of chenic acid for gallstone patients: reduction with bedtime administration and low cholesterol diet.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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