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pubmed-article:7071580pubmed:abstractTextLarge numbers of granulocytes can be collected repeatedly from the supernatant medium of long-term cultures of mouse bone marrow cells. A constant relationship was found between the number of adherent hematopoietic stem cells and the lifetime cell production per culture. The data indicate that there is a limit to the proliferative capacity of normal and of irradiated stem cells. A similar limitation was found in the production of marked granulocytes from clonal cultures of "beige" C57 (bg/bgJ) stem cells placed in limiting dilutions into stromal culture layers.lld:pubmed
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pubmed-article:7071580pubmed:articleTitleProliferative capacity of murine hematopoietic stem cells in vitro.lld:pubmed
pubmed-article:7071580pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7071580pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed