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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4540
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pubmed:dateCreated |
1982-6-24
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pubmed:abstractText |
Large numbers of granulocytes can be collected repeatedly from the supernatant medium of long-term cultures of mouse bone marrow cells. A constant relationship was found between the number of adherent hematopoietic stem cells and the lifetime cell production per culture. The data indicate that there is a limit to the proliferative capacity of normal and of irradiated stem cells. A similar limitation was found in the production of marked granulocytes from clonal cultures of "beige" C57 (bg/bgJ) stem cells placed in limiting dilutions into stromal culture layers.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1619-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7071580-Animals,
pubmed-meshheading:7071580-Bone Marrow Cells,
pubmed-meshheading:7071580-Cell Division,
pubmed-meshheading:7071580-Cells, Cultured,
pubmed-meshheading:7071580-Granulocytes,
pubmed-meshheading:7071580-Hematopoiesis,
pubmed-meshheading:7071580-Hematopoietic Stem Cells,
pubmed-meshheading:7071580-Mice,
pubmed-meshheading:7071580-Spleen
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pubmed:year |
1982
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pubmed:articleTitle |
Proliferative capacity of murine hematopoietic stem cells in vitro.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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