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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1982-6-14
|
| pubmed:abstractText |
Thallium-201 myocardial imaging was performed in dogs after pretreatment with grisorixin, which appeared to increase the myocardial uptake of Tl-201. This effect of grisorixin was found to be dose dependent, with an optimal dose of 60 microgram/kg. The myocardial-to-background ratio, which was 1.92 in the control dogs, rose to 4.45. The increase in the absolute myocardial uptake was demonstrated in guinea pigs that received Tl-201 after similar pretreatment with grisorixin. In the animals treated with 500 microgram/kg, the uptake of Tl-201 by the heart was 35% over the control value. With 60 microgram/kg grisorixin, the coronary blood flow increased from 40 to 176 ml/min 5 min after the injection. This dose, optimal for imaging, induced the maximum vasodilator effect with only a very slight concomitant increase in the left-ventricular pressure and myocardial contractility. Above 60 microgram/kg, grisorixin appeared to be a potent inotropic agent, whereas below this dose it showed only coronary vasodilator properties. Some evidence for an ionophore effect of this compound was found in dogs pretreated with 60 microgram/kg. In these the radionuclide was injected when the coronary vasodilatation had become insignificant, but a significant improvement of the M/B ratio was still evident.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nigericin,
http://linkedlifedata.com/resource/pubmed/chemical/Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Thallium,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/grisorixin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0161-5505
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
330-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7069497-Animals,
pubmed-meshheading:7069497-Anti-Bacterial Agents,
pubmed-meshheading:7069497-Blood Pressure,
pubmed-meshheading:7069497-Coronary Circulation,
pubmed-meshheading:7069497-Coronary Vessels,
pubmed-meshheading:7069497-Dogs,
pubmed-meshheading:7069497-Dose-Response Relationship, Drug,
pubmed-meshheading:7069497-Female,
pubmed-meshheading:7069497-Guinea Pigs,
pubmed-meshheading:7069497-Heart,
pubmed-meshheading:7069497-Male,
pubmed-meshheading:7069497-Myocardial Contraction,
pubmed-meshheading:7069497-Myocardium,
pubmed-meshheading:7069497-Nigericin,
pubmed-meshheading:7069497-Radioisotopes,
pubmed-meshheading:7069497-Thallium,
pubmed-meshheading:7069497-Tissue Distribution,
pubmed-meshheading:7069497-Vasodilator Agents
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Myocardial imaging in dogs treated with grisorixin: relationship between thallium-201 uptake and coronary blood flow.
|
| pubmed:publicationType |
Journal Article
|