Linked Life Data

7069445

Source:http://linkedlifedata.com/resource/pubmed/id/7069445

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-6-14
pubmed:abstractText
The lumbosacral spinal cord, lumbar roots, L5 spinal ganglion, L5 segmental nerve and entire lengths of the sciatic, tibial, peroneal and sural nerves were taken at postmortem examination from 2 patients with insulin-dependent diabetes mellitus (IDDM) and a predominantly sensory symmetric distal polyneuropathy and compared with 2 non-diabetic control patients. Sections from proximal to middle levels of sciatic nerves of these patients showed a remarkable variability in myelinated fiber (MF) density within and between fascicles. Roots and segmental nerves appeared to be unaffected. Sections of peroneal, tibial and sural nerves showed only severe and diffuse fiber loss. The findings suggest that multifocal lesions at upper levels of sciatic nerve can summate distally to produce a symmetric diabetic neuropathy. The findings, if confirmed by using quantitative approaches in larger numbers of patients, suggest an underlying interstitial pathological process rather than a metabolic process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
501-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Multifocal fiber loss in proximal sciatic nerve in symmetric distal diabetic neuropathy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Case Reports, Research Support, Non-U.S. Gov't