Linked Life Data

7068975

Source:http://linkedlifedata.com/resource/pubmed/id/7068975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 2 Suppl
pubmed:dateCreated
1982-6-24
pubmed:abstractText
Administration of oral vitamin A and the synthetic retinoids to humans and experimental animals has been accompanied by changes in lipid metabolism. these changes include alterations in serum, liver, and skin surface lipids. While the immediate cause(s) of the serum and liver changes remain(s) obscure, the skin surface lipid alterations appear to be secondary to changes in sebum production. The most marked effect of retinoid feeding seen in clinical or animal studies is that of hypertriglyceridemia. The increased serum triglycerides are found primarily in the very low-density lipoprotein (VLDL) fraction of the blood and occur during both the fasted and fed state. In rats, oral all-trans-retinoic acid, 13-cis-retinoic acid, and natural vitamin A have resulted in hypertriglyceridemia, while in man, 13-cis-retinoic acid, etretinate, and natural vitamin A have been reported to elicit this response. Current studies using the rat indicate that elevated serum triglycerides may be secondary to both increased liver secretion and decreased extrahepatic breakdown. Ongoing work from our laboratory and the possible primary causes of the systemic lipid changes are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0190-9622
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
664-74
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Changes in lipid metabolism during retinoid administration.
pubmed:publicationType
Journal Article