Linked Life Data

7067785

Source:http://linkedlifedata.com/resource/pubmed/id/7067785

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-6-14
pubmed:abstractText
Experiments carried out on seven adult baboons were addressed at specifying the participation of the cerebellar dentate nucleus (DN) in the control of duration and accuracy of a goal-directed movement. The visuo-motor task used in this experiment involved trained pointing movement towards stationary target. The monkeys trained to point with the index finger to a target light were required to perform stereotyped movements of constant amplitude and direction, or movements with variable amplitude and direction. Duration of response execution was measured by movement time and accuracy by terminal spatial errors. We analysed the effects of excluding the DN on the arm ipsilateral or contralateral to the partially inactivated nucleus. Two techniques have been used to impair the DN activity: in three monkeys the structure was reversibly cooled with a chronically implanted thermode; in four others partial electrolytic destruction of the DN was performed. In the arm ipsilateral to the lesioned DN we observed modifications of movement times, appearance of systematic errors with increased dispersion. Contralateral effects were restricted to movement times. Changes in movement times and spatial errors were studied over time (4 months) in permanently lesioned animals. Only the spatial dispersion presented a total recovery. These data show that the DN is concerned with the control of speed and accuracy during the execution of visually triggered movements in monkeys. Moreover comparison of results concerning ipsilateral and contralateral effects of DN dysfunction on movement times and errors, and evidence of different time course of recovery in these variables, suggest a differential control exerted by the DN on speed and accuracy of goal directed movements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-38
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Participation of the cerebellar dentate nucleus in the control of a goal-directed movement in monkeys. Effects of reversible or permanent dentate lesion on the duration and accuracy of a pointing response.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't