Linked Life Data

7067031

Source:http://linkedlifedata.com/resource/pubmed/id/7067031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-6-21
pubmed:abstractText
In 1976, we decided to review the files of the scoliosis clinic at Ste-Justine Hospital in Montreal. We found 2,237 patients with scoliosis, 212 of them are classified as congenital. At this time, congenital scoliosis were the major unresolved problems. We decided to look at an experimental model, to study the physio-pathological mechanism of the induction of these malformations. We chose the mouse as the experimental animal, and "hypobaric hypoxia" as the teratogenic agent. With this model, we can produce, malformations at different levels of the spine, if we treat at different days of pregnancy. For example, if we treat the mothers in the 10th day of her pregnancy, we get 90% of malformed embryos, at the lumbar level. All the malformations reproduced in the mice, are similar to those found in humans. We have also demonstrated no difference in the morphology of these malformations from birth to maturity, in contradiction with Epstein, who said that the majority of cleft vertebrae will disappear with bone maturation. We have also demonstrated that these malformations are present in the cartilaginous stage of development of the vertebral column. Our findings are in contradiction with Nassim's who stated, that congenital vertebral malformations are produced by an abnormal ossification process on a normal cartilage primum. Finally, our findings are in agreements with those of Dr. Uhthoff, who showed that congenital vertebral malformations are present in cartilaginous stage of development in human embryos.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0180-5738
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
[Moderate hypobaric hypoxia used as an inducer of congenital vertebral malformation in mouse embryo (author's transl)].
pubmed:publicationType
Journal Article, English Abstract