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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1982-5-21
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pubmed:abstractText |
A foundry worker developed dyspnea and a restrictive breathing defect after being exposed to diphenylmethane diisocyanate (MD) at work. His symptoms and lung function impairment subsided a few weeks after he left work. Specific inhalation challenges with the offending agent induced general malaise together with a significant increase in body temperature and leukocyte count as well as a significant decrease in forced vital capacity and transfer factor. Total antibody activity to a MDI human serum albumin (MDI-HSA) conjugate was detected by ammonium sulfate precipitation. Specific IgG antibodies were demonstrated by the enzyme-linked immunoabsorbent (ELISA) technique. Thus, it was found that MDI exposure can cause hypersensitivity pneumonitis and induce the production of specific antibodies.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7065501-Adult,
pubmed-meshheading:7065501-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:7065501-Cyanates,
pubmed-meshheading:7065501-Humans,
pubmed-meshheading:7065501-Isocyanates,
pubmed-meshheading:7065501-Male,
pubmed-meshheading:7065501-Occupational Diseases,
pubmed-meshheading:7065501-Respiratory Function Tests
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pubmed:year |
1982
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pubmed:articleTitle |
Occupational hypersensitivity pneumonitis after exposure to diphenylmethane diisocyanate.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
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