Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-5-21
pubmed:abstractText
In a study of 300 Alaskan Malamutes, dwarfism was shown to be an autosomal recessive inherited disease with complete penetrance that resulted in disturbed endochondral bone formation. Osseous growth disturbance was manifest at the metaphyses of tubular bones. Clinical and radiographic changes were very similar to those of rickets, although appositional bone formation rates were normal. Serum calcium, phosphorus, and alkaline phosphatase were within normal limits. Urinary excretion of calcium, phosphate, and amino acids were normal. Excess matrix was formed in the zone of cartilage cell proliferation, and the matrix persisted in the growth plate. Normal stresses resulted in microfractures in the metaphyses with subsequent interference of vascular penetration into the zone of degenerated cartilage cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13354850, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13532159, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13603078, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13621351, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13719292, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13915518, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-13917203, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-14127791, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-14223656, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-14227699, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-14459139, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4114784, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4163074, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4265987, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4278122, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4333078, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4349944, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4349945, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4537780, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4540246, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4636684, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4715956, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-4980788, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-5101825, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-5304381, http://linkedlifedata.com/resource/pubmed/commentcorrection/7065114-5337114
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-36
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Dwarfism in Alaskan malamutes: a disease resembling metaphyseal dysplasia in human beings.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't