Linked Life Data

7064495

Source:http://linkedlifedata.com/resource/pubmed/id/7064495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-5-12
pubmed:abstractText
Adult female Wistar rats were fed continuously over a period of 65 days with a diet containing 0.05% hexachlorobenzene (HCB), silymarin (100 mg/kg) or (+)-cyanidanol-3 (150 mg/kg) alone or together with HCB. On day 49 the porphyrins were increased in the cyanidanol-HCB-group in contrast to the silymarin-HCB- and the HCB-group which showed lower levels during the whole experiment. Compared with the other groups--aminolevulinic acid and porphobilinogen were increased in the cyanidanol/HCB-group. Silymarin and cyanidanol had no effect on the formation of experimental porphyria. On the other hand, silymarin is a stronger inducer of the mixed function monooxygenase system than cyanidanol. The type of the cytochrome P-450 induced by the substances could not be identified with the help of different type-specific inhibitors.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0044-2771
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-6
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Influence of silymarin and (+)-cyanidanol-3 on the HCB-induced porphyria in rats (author's transl)].
pubmed:publicationType
Journal Article, English Abstract