Linked Life Data

7061448

Source:http://linkedlifedata.com/resource/pubmed/id/7061448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-5-27
pubmed:abstractText
Using principles developed by Kacser and Burns ((1973) in Rate Control of Biological Processes (Davies, D. D., ed) pp. 65-104, Cambridge University Press, London) and Heinrich and Rapoport ((1974) Eur. J. Biochem. 42, 97-105), inhibitor titration studies were carried out in order to quantify the amount of control (control strength) exerted by different steps in oxidative phosphorylation on the rate of mitochondrial oxygen uptake. In the resting state of respiration, nearly all control is exerted by the passive permeability of the mitochondrial inner membrane to protons. In the intermediate states and even in the active state of respiration, control is distributed among different steps including the adenine nucleotide translocator and cytochrome c oxidase. It is therefore not possible to speak of the rate-limiting step in oxidative phosphorylation. Since both the adenine nucleotide translocator and cytochrome c oxidase appear to be rate-controlling, hypotheses suggesting that respiration is fully controlled by either of these two steps alone need to be modified.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2754-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Quantification of the contribution of various steps to the control of mitochondrial respiration.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't