Linked Life Data

7061180

Source:http://linkedlifedata.com/resource/pubmed/id/7061180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-5-12
pubmed:abstractText
The pharmacokinetic properties of a single 200-mg dose of tiapride were studied in eight healthy volunteers (four males and four females). The drug was administered by i. v., i. m., and p. o. routes (solution and tablets). Plasma and urine concentrations were determined by a high-performance liquid chromatography. The results were compatible with a linear two-compartment model. The half-life in the disposition phase ranged from 2.19 h to 4.55 h (mean 3.23 h). Peak plasma concentrations were always reached within 2 h. The percentage of absorption of the i. m. and the two p. o. formulations varied from 49.3 to 98.9%. The renal clearance varied from 11.8 to 24.9 l/h. The drug was mainly eliminated in unmetabolized form in the urine (75.6%).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
62-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Pharmacokinetics of tiapride and absolute bioavailability of three extravascular forms.
pubmed:publicationType
Journal Article