Linked Life Data

7060659

Source:http://linkedlifedata.com/resource/pubmed/id/7060659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-5-12
pubmed:abstractText
Thiamphenicol (TAP) administered subcutaneously for 4 days via a dialysis bag to bled mice, caused a total inhibition of the differentiation of BFUE into CFUE. The femoral BFUE numbers remained constant whereas the CFUE compartment was virtually absent. The proliferation of CFUs and BFUE was inhibited as well. The granuloid cell line was hardly affected. Shortly after removal of the drug, proliferation of CFUs and BFUE was resumed and a specific time sequence in the regeneration of erythropoiesis in marrow and spleen was observed. A decline in the number in BFUE in the femoral marrow was followed by an increase in the total CFUE in the marrow and an increase in the number of BFUE in the femoral marrow was followed by an increase in the total CFUE in the marrow and an increase in the number of BFUE in the spleen. Maximal erythropoiesis in the spleen occurred 1-2 days later than in marrow. The first wave of erythropoiesis in marrow was followed by a second one leading to high normal values of femoral stem cells. Spleen erythropoiesis consisted of one wave of proliferation and differentiation. The experimental system offers a valuable model for studying certain aspects of erythropoiesis and provides good starting material for CFUE isolation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-43
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The regeneration of stem cells after a bone marrow depression induced by thiamphenicol.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't