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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1982-5-12
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pubmed:abstractText |
Active hydroxy metabolites of imipramine (IMI) and desipramine (DMI) have been quantified in plasma and cerebrospinal fluid (CSF) from patients at steady-state. In plasma of prepubescent boys and adults the concentration of unconjugated 2-hydroxyimipramine is only 15% to 25% that of IMI; 2-hydroxydesipramine (OH-DMI) concentration, however, is usually 50% that of DMI and in some cases OH-DMI is the predominant compound. In CSF from adult patients the ratio of concentrations of OH-DMI/DMI is higher than in plasma. Judging from the CSF/plasma ratio 12% of DMI exists in the free form at steady state, whereas 16% of OH-DMI is free (P less than 0.02). There is no evidence for saturation of hydroxylation within the therapeutic dose and concentration ranges investigated. On the basis of a steady-state OH-DMI/DMI ratio of less than 1/30 in plasma 5% of the population studied could be classified as deficient DMI hydroxylators. This in the same as the incidence of deficient debrisoquine hydroxylators reported in other populations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-401
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7060321-Adolescent,
pubmed-meshheading:7060321-Adult,
pubmed-meshheading:7060321-Aged,
pubmed-meshheading:7060321-Biotransformation,
pubmed-meshheading:7060321-Child,
pubmed-meshheading:7060321-Desipramine,
pubmed-meshheading:7060321-Double-Blind Method,
pubmed-meshheading:7060321-Enuresis,
pubmed-meshheading:7060321-Female,
pubmed-meshheading:7060321-Humans,
pubmed-meshheading:7060321-Imipramine,
pubmed-meshheading:7060321-Male,
pubmed-meshheading:7060321-Middle Aged
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pubmed:year |
1982
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pubmed:articleTitle |
Active metabolites of imipramine and desipramine in man.
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pubmed:publicationType |
Journal Article
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