Linked Life Data

7059413

Source:http://linkedlifedata.com/resource/pubmed/id/7059413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-5-21
pubmed:abstractText
1 The pharmacokinetics of cimetidine and its sulphoxide metabolite was studied after a single intravenous dose of 200 mg cimetidine in nine patients with normal renal function and ten patients with severe renal failure on regular haemodialysis and during continuous oral cimetidine treatment in ten patients with normal renal function and 31 patients with different degrees of renal failure. 2 In normal renal function a mean of 47.3% of the single intravenous dose was excreted as unchanged drug and 12.8% as cimetidine sulphoxide. The mean plasma elimination half-life (T1/2) of cimetidine was 2.0 h and of cimetidine sulphoxide 1.7 h. 3 In severe renal failure a mean of 2.2% of the single intravenous dose was excreted as unchanged drug and 0.5% as cimetidine sulphoxide. The mean plasma T1/2 of cimetidine was 3.9 h. The plasma concentrations of the sulphoxide metabolite increased successively with time after dosing and no elimination phase was observed still 9 h after dose. The mean non-renal clearance of cimetidine was 210 ml/min and lower than in normal renal function, suggesting decreased metabolism of cimetidine in uraemia. 4 During continuous oral cimetidine treatment in patients with normal renal function and in patients g and no elimination phase was observed still 9 h after dose. The mean non-renal clearance of cimetidine was 210 ml/min and lower than in normal renal function, suggesting decreased metabolism of cimetidine in uraemia. 4 During continuous oral cimetidine treatment in patients with normal renal function and in patients g and no elimination phase was observed still 9 h after dose. The mean non-renal clearance of cimetidine was 210 ml/min and lower than in normal renal function, suggesting decreased metabolism of cimetidine in uraemia. 4 During continuous oral cimetidine treatment in patients with normal renal function and in patients with different degrees of renal failure given reduced doses of cimetidine the plasma concentrations of the sulphoxide metabolite were higher with decreasing renal function. The mean plasma T1/2 of cimetidine was 3.1 h in mild renal dysfunction (creatinine clearance 50-75 ml/min) and 4.5 h in severe renal failure (creatinine clearance 5-15 ml/min) and of cimetidine sulphoxide 5.3 and 14.4 h respectively. 5 Toxicity studies of cimetidine sulphoxide may be needed to assess if high plasma concentrations of the sulphoxide metabolite in severe renal failure are of clinical significance.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-23270, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-342062, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-426403, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-435708, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-4555879, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-456399, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-589306, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-620910, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-620915, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-660782, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-7004992, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-701432, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-70726, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-7363531, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-7387814, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-7428801, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-7463957, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-760739, http://linkedlifedata.com/resource/pubmed/commentcorrection/7059413-84204
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-70
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't