Linked Life Data

7059353

Source:http://linkedlifedata.com/resource/pubmed/id/7059353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-12
pubmed:abstractText
The administration of the antilipolytic agents sodium nicotinate (1 mmole/kg i.p.) or sodium 5-methylpyrazole-3-carboxylate (0.5 or 1.0 mmole/kg i.p.) to alloxan-diabetic rats produced a significant reduction in the plasma concentration of free fatty acids and a slight reduction in blood glucose concentration. The concentrations in the freeze-clamped heart of citrate , acetyl CoA, Glucose-6-phosphate and fructose-6-phosphate were increased in untreated alloxan-diabetic rats relative to normoglycaemic controls. Treatment of alloxan-diabetic rats with the antilipolytic agents or insulin (60 U/kg i.p.) lowered these increased concentrations of metabolites in the heart. Treatment of the diabetic rats with the antilipolytic agents also produced an increase in the activity of pyruvate dehydrogenase in heart, but only treatment with 5-methylpyrazole-3-carboxylate had a significant effect on the activity of the enzyme in freeze-clamped soleus muscle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The effect of 5-methylpyrazole-3-carboxylate and nicotinic acid on abnormalities of carbohydrate metabolism in alloxan-diabetic rat muscle.
pubmed:publicationType
Journal Article