Linked Life Data

7058896

Source:http://linkedlifedata.com/resource/pubmed/id/7058896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-20
pubmed:abstractText
It has been proposed that bidirectional and concentration-dependent fluxes of digestive enzymes across pancreatic acinar cell membranes account for secretion. One implication of such a model is that protein secretion should be a function of fluid outflow, inasmuch as flow would be required to generate the necessary concentration gradient by carrying away secreted material. In an earlier study (Science 204: 1212, 1979) when fluid flow was decreased by a backpressure applied to fluid in the pancreatic duct, proportional reductions in protein secretion occurred. The present study uses metabolic rather than mechanophysical methods to decrease flow, reduction of the sodium concentration of the medium bathing the pancreas, or addition of the Na+-K+-ATPase inhibitor ouabain. Both treatments produced similar results: decreases in protein output synchronous with and proportional to the observed decreases in flow. Essentially the same relationship was seen when flow was reduced during protein secretion augmented by the secretagogue cholecystokinin-pancreozymin. These results suggest that the reduction in flow rate (whether produced mechanically or chemically) was the variable directly responsible for the decrease in protein secretion by the acinar cell.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
242
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G32-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Nature of flow dependence of protein secretion by the exocrine pancreas.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't