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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1982-4-20
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pubmed:abstractText |
A series of new 2-(phenylalkyl)oxirane-2-carboxylic acids has been synthesized and studied for its effects on the concentration of blood glucose. Most of the compounds exhibit remarkable blood glucose lowering activities in fasted rats. Structure-activity studies reveal that substituents like Cl or CF3 on the phenyl ring and a chain length of three to five carbon atoms lead to the most effective substances. Among these compounds, ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (36) exhibits the most favorable activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7057414-Animals,
pubmed-meshheading:7057414-Blood Glucose,
pubmed-meshheading:7057414-Carboxylic Acids,
pubmed-meshheading:7057414-Chemical Phenomena,
pubmed-meshheading:7057414-Chemistry,
pubmed-meshheading:7057414-Epoxy Compounds,
pubmed-meshheading:7057414-Ethers, Cyclic,
pubmed-meshheading:7057414-Female,
pubmed-meshheading:7057414-Hypoglycemic Agents,
pubmed-meshheading:7057414-Lethal Dose 50,
pubmed-meshheading:7057414-Male,
pubmed-meshheading:7057414-Muridae,
pubmed-meshheading:7057414-Rats,
pubmed-meshheading:7057414-Rats, Inbred Strains,
pubmed-meshheading:7057414-Structure-Activity Relationship
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pubmed:year |
1982
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pubmed:articleTitle |
Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives.
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pubmed:publicationType |
Journal Article
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