Linked Life Data

7056806

Source:http://linkedlifedata.com/resource/pubmed/id/7056806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-12
pubmed:abstractText
The metabolism of [14C]7-methylbenz[c]acridine, a weakly carcinogenic polycyclic aza aromatic hydrocarbon, was studied in rates in vivo, and in rat hepatocytes and hepatic microsomes. Evidence for oxidation of the methyl group and excretion of 7-hydroxymethylbenz[c]acridine and benz[c]acridine-7-carboxylic acid in rat bile was obtained by thin-layer chromatography. A reversed-phase high-performance liquid chromatographic separation of metabolites was developed and chromatographic profiles of metabolites found in vivo and formed in vitro are presented. Several synthetic potential oxidation products were used to characterise the chromatographic profiles and evidence for the in vitro formation of 7-hydroxymethylbenz[c]acridine and 5,6-dihydro-5,6-dihydroxy-7-methylbenz[c]acridine was obtained.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
227
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-57
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Thin-layer chromatographic and high-performance liquid chromatographic separation of metabolites of the weak carcinogen, 7-methylbenz[c]acridine.
pubmed:publicationType
Journal Article