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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1982-3-22
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pubmed:abstractText |
Groups of specific pathogen-free guinea pigs were randomly assigned to purified, isocaloric diets containing either 30%, 20%, or 10% casein, or commercial stock diet. Each animal was vaccinated subcutaneously with viable bacille Calmette-Guerin (BCG). Seven weeks post-vaccination, groups of guinea pigs from each diet treatment were skin tested with purified protein derivative (PPD) and killed. Animals fed the 10% casein diet exhibited significant reductions in body weight, serum albumin, and hemoglobin levels. Significantly greater number of viable BCG were recovered from the inguinal lymph nodes of malnourished (10% casein) animals than from 30% casein or stock control groups. Skin test responses to PPD were completely absent or markedly suppressed in the 20% and 10% casein groups. Lymphocyte blastogenesis following in vitro stimulation of peripheral blood lymphocytes with a polyclonal T cell mitogen was also reduced inthe 10% casein group. Circulating levels of serum IgM and C3 complement were not influenced by nutritional status while levels of IgG were elevated in 10% and 20% casein groups. These results suggest that malnutrition may impair cell-mediated immune responses on which the efficacy of BCG vaccine depends.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BCG Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Globulins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3166
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-74
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7054464-Animals,
pubmed-meshheading:7054464-Antibody Formation,
pubmed-meshheading:7054464-BCG Vaccine,
pubmed-meshheading:7054464-Blood Proteins,
pubmed-meshheading:7054464-Body Weight,
pubmed-meshheading:7054464-Dietary Proteins,
pubmed-meshheading:7054464-Female,
pubmed-meshheading:7054464-Guinea Pigs,
pubmed-meshheading:7054464-Hemoglobins,
pubmed-meshheading:7054464-Hypersensitivity, Delayed,
pubmed-meshheading:7054464-Immunity, Cellular,
pubmed-meshheading:7054464-Lymph Nodes,
pubmed-meshheading:7054464-Protein Deficiency,
pubmed-meshheading:7054464-Serum Globulins,
pubmed-meshheading:7054464-Spleen
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pubmed:year |
1982
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pubmed:articleTitle |
Immune responses in malnourished guinea pigs.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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