Linked Life Data

7052488

Source:http://linkedlifedata.com/resource/pubmed/id/7052488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-6-23
pubmed:abstractText
Leukotriene C-1 (LTC-1), a recently characterized potent agonist in bioassays for the slow reacting substance of anaphylaxis (SRS-A), was tested for electrophysiological effects on central neurons. LTC-1 consistently elicited a unique prolonged excitatory action on cerebellar Purkinje (P) cells when administered locally by pressure ejection from a multibarreled micropipette. This excitation could be reversed by subsequent pressure ejection of FPL 55712 (FPL), a SRS-A end-organ antagonist. Prior application of FPL prevented the LTC-1-induced responses altogether. Heat-inactivated LTC-1 had no effect on P cell discharge. These data suggest that LTC-1, as has been recently found with many other peripherally acting neurohormones, may also function to regulate excitability of central neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Leukotriene C elicits a prolonged excitation of cerebellar Purkinje neurons.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't