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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1982-12-3
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pubmed:abstractText |
Eight patients with Ph1-positive chronic myelogenous leukemia (CML) in chronic or accelerated phase received high-dose cyclophosphamide, total body irradiation, and bone marrow transplantation from an HLA-identical sibling donor. All patients had prompt engraftment and achieved complete hematologic remission. Six patients remain alive and in continuous remission with a normal bone marrow karyotype 3-20+ mo posttransplant. One patient died from cytomegalovirus interstitial pneumonitis. Only one patient who was transplanted in accelerated phase relapsed 6.5 mo posttransplant and died in blast crisis. High-dose combined modality therapy is capable of producing sustained complete remissions in patients with CML treated during chronic or accelerated phase.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
60
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
1038-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7052161-Adult,
pubmed-meshheading:7052161-Bone Marrow Transplantation,
pubmed-meshheading:7052161-Chromosome Aberrations,
pubmed-meshheading:7052161-Cyclophosphamide,
pubmed-meshheading:7052161-Humans,
pubmed-meshheading:7052161-Leukemia, Myeloid,
pubmed-meshheading:7052161-Whole-Body Irradiation
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pubmed:year |
1982
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pubmed:articleTitle |
Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|