Linked Life Data

7044681

Source:http://linkedlifedata.com/resource/pubmed/id/7044681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Pulmonary edema after Escherichia coli (E. coli) endotoxin administration is characterized by marked pulmonary hypertension adn microvascular protein permeability. Conceivably, therapy directed at reducing pulmonary arterial hypertension should improve right ventricular mechanics and potentially may decrease the amount of edema formed. We studied the effect of nitroprusside (NP) on pulmonary hypertension, transvascular fluid filtration rate (reflected in lung lymph flow (QL)) and microvascular protein permeability after E. coli endotoxin lung injury. Using the unanesthetized sheep lung lymph preparation, we found the initial pulmonary hypertension after endotoxin infusion refractory to NP. One h after endotoxin, NP significantly reduced the pulmonary artery pressure (P PA) compared to the endotoxin control group. During NP infusion, cardiac output increased a P PA decreased. We found no difference in QL during NP infusion compared to the control group. After cessation of NP infusion, QL increased, whereas protein clearance (QL x lymph protein content) remained constant. We found no beneficial effect of nitroprusside on transvascular fluid flux and microvascular protein permeability after E coli endotoxin injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0090-3493
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-31
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of nitroprusside on pulmonary hypertension and lung fluid balance after E. coli endotoxin.
pubmed:publicationType
Journal Article