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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1982-7-22
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pubmed:abstractText |
We studied 21 strains of amikacin-resistant Serratia marcescens from three different U.S. cities, Twenty of the 21 strains contained conjugative R plasmids mediating gentamicin and tobramycin resistance. Amikacin-resistant S. marcescens from two cities predominated in protracted outbreaks. Conversely, the amikacin-resistant Charleston strain (serotype 02/03:nonmotile) was isolated from only four patients during an outbreak of gentamicin- and tobramycin resistant, amikacin-susceptible S. marcescens (serotype O19:O17). Five different representative amikacin-resistant S. marcescens, each containing a single conjugative plasmid, elaborated a nontransferable aminoglycoside (6')-N-acetyltransferase [AAC(6')] with similar substrate profiles in addition to other transferable aminoglycoside-modifying enzymes. One amikacin-resistant S. marcescens cured of its plasmid and another naturally occurring plasmid-free amikacin-resistant S. marcescens elaborated only AAC(6')-1. These data support the concept of a chromosomal locus in S. marcescens for AAC(6')-1 which commonly coexists with plasmid-mediated genes for aminoglycoside-modifying enzymes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-108221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-15828191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-166284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-232298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-328950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-360974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-371541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-415674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-426512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-4581231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-46385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-5325707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-537886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-6271046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-649533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-6768292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-6966629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7009583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7019356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7023310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7028654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-70654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7263569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-7411116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-76382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-811159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7044303-825583
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7044303-Acetyltransferases,
pubmed-meshheading:7044303-Amikacin,
pubmed-meshheading:7044303-Aminoglycosides,
pubmed-meshheading:7044303-Anti-Bacterial Agents,
pubmed-meshheading:7044303-Chromosomes, Bacterial,
pubmed-meshheading:7044303-Conjugation, Genetic,
pubmed-meshheading:7044303-DNA, Bacterial,
pubmed-meshheading:7044303-Drug Resistance, Microbial,
pubmed-meshheading:7044303-Escherichia coli,
pubmed-meshheading:7044303-Kanamycin,
pubmed-meshheading:7044303-Plasmids,
pubmed-meshheading:7044303-Serratia marcescens,
pubmed-meshheading:7044303-Substrate Specificity
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pubmed:year |
1982
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pubmed:articleTitle |
Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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