Linked Life Data

7042906

Source:http://linkedlifedata.com/resource/pubmed/id/7042906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-7-19
pubmed:abstractText
The effect of various culture media on K99 antigen production by enterotoxigenic Escherichia coli strains of bovine origin was investigated by slide agglutination tests, enzyme-linked immunosorbent assays and in vitro attachment to intestinal villi. A-Alanine at concentrations higher than 0.7 g 1(-1) was responsible for the inhibition of K99 synthesis observed on media rich in amino acids. The increased inhibitory activity of L-alanine in glucose-rich media after autoclaving suggested the formation of inhibitory products via Maillard's reaction. Of various L-alanine derivatives tested, only those that hydrolysed to L-alanine were inhibitory. L-Alanine analogues were without effect and the addition of 10 mM-cyclic AMP did not overcome the repression of K99 biosynthesis by L-alanine. Enzymes involved in cell wall synthesis such as L-alanine racemase or D-alanyl-D-alanine synthetase were evidently were evidently unaffected by L-alanine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1287
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
463-70
pubmed:dateRevised
2005-1-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Inhibition of K99 antigen synthesis by L-alanine enterotoxigenic Escherichia coli.
pubmed:publicationType
Journal Article